"

rabybet雷竞技官网

"
rabybet雷竞技官网
> 新闻 > 学术报告
新闻
学术报告
学术报告:植物病理学系学术报告
发布日期:2022-09-13 浏览次数: 信息来源:植保学院 字号:[ ]

报告题目: Engineering plant immune receptors to combat blast disease

报告人: Mark J Banfield, John Innes Centre

时间:2022915日(周四)下午16:00

地点:加入 Zoom 会议

https://us06web.zoom.us/j/88335405380?pwd=QlM0akdQV3ZXYnQvTkJqQmxqcU5lUT09

会议号:883 3540 5380

密码:448554

 

摘要:

A subset of plant intracellular NLR immune receptors detect effectors, proteins secreted by phytopathogens to promote infection, through unconventional integrated domains which resemble the effector’s host targets. Direct binding of effectors to these integrated domains activates plant defences. The rice NLR receptor Pik-1 binds the Magnaporthe oryzae effector AVR-Pik through an integrated heavy metal-associated (HMA) domain, but there are AVR-Pik variants that evade detection. We have recently exploited knowledge of the biochemical interactions between AVR-Pik and a putative host HMA domain containing target, OsHIPP19, to engineer novel Pik-1 variants that respond to these stealthy effectors. We demonstrate that extended recognition profiles of engineered Pikp-1 variants correlate with effector binding in planta and in vitro, and with the gain of new contacts across the effector/HMA interface. Importantly, transgenic rice producing the engineered Pikp-1 variants were resistant to blast fungus isolates containing previously unrecognized effector variants. These results demonstrate that effector target-guided engineering of NLR receptors can provide new-to-nature disease resistance in crops. Further, we have recently extended our NLR engineering studies to include other M. oryzae effectors shown to bind host HMA proteins.

 

报告人简介:

Prof. Mark Banfield is a Group Leader at the John Innes Centre, Norwich, UK. He performed his PhD at The University of Bristol (UK, 1997). He was a postdoc in Bristol (UK), Auckland (New Zealand), then Bristol again before being awarded a Royal Society University Research Fellowship and moving to the University of Newcastle (UK) as a Lecturer. In 2008 he moved to the John Innes Centre to start a research programme investigating the structure and function of effectors from filamentous plant pathogens (oomycetes and fungi). Early work in this area led to expanding his research to include the molecular mechanisms of receptors in the plant immune system, although he retains interests in the virulence activity of pathogen effectors. Recent research has focused on structure-led engineering of integrated domains in plant intracellular immune receptors (NLRs) for expanded recognition and diseases resistance profiles.


欢迎感兴趣的老师和同学们参加!

【打印本页】 【关闭本页】
0
rabybet雷竞技官网

<nav id="wmzyq"><optgroup id="wmzyq"></optgroup></nav><big id="wmzyq"><acronym id="wmzyq"></acronym></big>

    <nav id="wmzyq"><listing id="wmzyq"></listing></nav>
    1. <form id="wmzyq"><legend id="wmzyq"></legend></form>
      <form id="wmzyq"><legend id="wmzyq"></legend></form><dd id="wmzyq"></dd>
    2. <form id="wmzyq"><legend id="wmzyq"></legend></form>
    3. "